Sulfatides partition disabled-2 in response to platelet activation.
BACKGROUND:Platelets contact each other at the site of vascular injury to stop bleeding.One negative regulator of platelet aggregation is Disabled-2 (Dab2), which is released to the extracellular surface upon platelet activation.Dab2 inhibits platelet aggregation through its phosphotyrosine-binding (PTB) domain by competing with fibrinogen for alph